Preheat oven to 350 degrees.
Sift all-purpose flour into a mixing bowl.
Add baking powder, baking soda and salt to the flour and whisk place to the side.
In the bowl of an electric stand mixer using a paddle, whip together butter, sugar until pale and fluffy
Mix in egg, then the egg whites one at a time, add in the vanilla with 2nd egg white.
In the liquid measuring cup add buttermilk,and lime juice whisk together
Begin to mix all ingredients together by adding 1/3 of the flour mixture alternating with 1/2 of the buttermilk mixture and mixing just until combined after each addition.
Fill 12 paper lined muffin cups only to 3/4 full so you may get more than 12
Bake in preheated oven until toothpick inserted the center cupcake comes out clean, about 18 - 20 minutes.
Remove from oven and allow to cool several minutes